“Opening flower” William Sharp, 1854

“Out of the 10,798 patients subjected to testing, 29 (0.27%)
exhibited a positive reaction to cocamidopropyl betaine.”[1]

[1] Kim, D., Seok, J.K., Kim, M. et al. Safety assessment of cocamidopropyl betaine, a cosmetic ingredient. Toxicol Res. 40, 361–375 (2024). https://doi.org/10.1007/s43188-024-00243-2